2001-2010 Consultant psychiatrist, University Hospital Lübeck 2007-2009 Visiting professor at the Center for Cognitive Medicine, University of Illinois at Chicago, USA, 2010-2020 Deputy director and section head for psychotic disorders, Department of Psychiatry and Psychotherapy, University Hospital Münster 2014-2020 Speaker of the Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, WWU Münster 2018 Visiting professor Institute of Social Scienes and Psychology, Western Sydney University, Australia Since 2020 Co-Head of the Track for Psychotic Disorders and Early Intervention (together with C. Andreou), University Hospital Schleswig-Holstein
Prof. Lencer pursues clinical work and research activities in parallel following a translational approach by using knowledge from non-human primate studies to advance understanding of disease mechanisms in brain disorders and develop novel therapeutic appraoches, e.g. cutting-edge brain stimulation techniques. This is exemplified in her most recent project on individually optimized mc-tDCS (DFG, LE 1122/7-1).
(1) Neural and functional disease mechanisms involved in major psychiatric disorders by studying familial neurobiological markers, e.g. visual information processing and eye movement control using novel methodological approaches from brain imaging, neurophysiology, brain stimulation (e.g. t-DCS), and molecular genetics in large sample multi-site studies. (2) Studying psychological aspects of self-stigmatization and attitude towards medication to foster treatment adherence.
Popovic D, …..Lencer R, ……., Borgwardt S, Koutsouleris N; PRONIA Consortium (2020) Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes. Biol Psychiatry 2020 May 26;S0006- 3223(20)31626-7. doi: 10.1016/j.biopsych.2020.05.020
Lencer R et al. (2019) Alterations in intrinsic fronto-thalamo-parietal connectivity are associated with cognitive control deficits in psychotic disorders. Hum Brain Map 40(1):163-174. https://doi.org/10.1002/hbm.24362
Feldhaus T, …….. Lencer R. (2018) The impact of self-stigmatization on medication attitude in schizophrenia patients. Psychiatry Res 261:391-399. doi: 10.1016/j.psy- chres.2018.01.012
Lencer R et al. (2017). Genome-wide association studies of smooth pursuit and anti- saccade eye movements in psychotic disorders: findings from the B-SNIP study. Transl. Psychiatry 7, e1249; https://doi.org/10.1038/tp.2017.210
Lencer R, et al. (2008) Effects of second-generation antipsychotic medication on smooth pursuit performance in antipsychotic-naïve schizophrenia. Arch Gen Psychiatry 65:1146-1154
Believing that tight collaborations between different disciplines from basic neuroscience to clinical research across Germany are heavily needed to face the challenges of future mental health care I am very enthusiastic about bringing in my extensive clinical research expertise gained in large, international multisite consortia including recruitment, deep phenotyping for biomarkers, data management and analyses to build the German Center for Mental Health.